Enhancing Optical Microscopy with Quantum Entanglement

Xin Tong, Yide Zhang and Lihong V. Wang

Drawing on the unique properties of entangled photons, quantum approaches can overcome the limitations of classical methods, enhance spatial resolution and reduce stray light and shot noise.

The quantum imaging team at the Caltech Optical Imaging Laboratory. From left: Xin Tong, Zhe He, Lihong Wang and Yide Zhang. [L. Hayashida, California Institute of Technology]

Ever since Antonie van Leeuwenhoek’s first microscope in the 17th century, optical imaging has been widely used to noninvasively investigate the structures and dynamics of physical and biological systems. The interaction of nonionizing light with molecules provides rich molecular information about biological samples, aided by the convenience and compactness of optical systems. Optical imaging has thus served as the workhorse behind a wide variety of discoveries by biological researchers and medical practitioners.

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